巴西专利BR112017000463B1 vascular access device

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专利摘要:
A vascular access device includes an antimicrobial coating that provides resistance to twisting a catheter. The antimicrobial coating can extend over a length of the catheter to provide antimicrobial protection when the catheter is inserted into the patient's vasculature. The antimicrobial coating can also increase the effective catheter diameter to minimize the likelihood of the catheter becoming twisted.
公开号:BR112017000463B1
申请号:R112017000463-1
申请日:2015-07-06
公开日:2020-11-17
发明作者:Jonathan Karl Burkholz；Siddarth K. Shevgoor；Tony Farnsworth Adams
申请人:Becton, Dickinson And Company；
IPC主号:

专利说明:

BACKGROUND OF THE INVENTION
[001] The present invention generally relates to vascular access devices that include an antimicrobial coating. In particular, the present invention is directed to an antimicrobial coating that forms a torsion resistant feature on a vascular access device.
[002] It is increasingly common for vascular access devices, such as catheters, to include an antimicrobial coating to minimize the occurrence of infections caused by the use of the vascular access device. For example, catheters often include an antimicrobial lubricant that provides lubrication during insertion of the catheter into the patient's vasculature and then provides antimicrobial protection while the catheter is inserted.
[003] A problem that exists with the use of current antimicrobial coatings is the risk of toxicity caused when excess antimicrobial agents enter the bloodstream or are distributed to a confined location. In order to obtain antimicrobial protection for a substantial period of time (for example, the entire time the catheter is inserted), a significant amount of antimicrobial lubrication must be present on the catheter. With the use of significant amounts of lubrication, there is a risk that a very high concentration of antimicrobial agents will be distributed.
[004] Another problem that exists with the use of catheters is torsion. For example, when a peripheral intravenous catheter is inserted into the patient's vasculature, it will typically be folded at the point, where the catheter exits the catheter adapter (for example, due to the catheter adapter being placed flat on the patient's skin) and possibly where the catheter enters through the patient's skin or vasculature. This fold can often result in twists that limit or prevent fluid flow through the catheter. BRIEF SUMMARY OF THE INVENTION
[005] The present invention extends to vascular access devices that include an antimicrobial coating that provides torsion-resistant catheter. The antimicrobial coating can extend over a length of the catheter to provide antimicrobial protection when the catheter is inserted into the patient's vasculature. The antimicrobial coating can also increase the effective catheter diameter to minimize the likelihood of the catheter becoming twisted.
[006] In one embodiment, the present invention is implemented as a vascular access device. The vascular access device includes a catheter adapter, a catheter that extends distally from the catheter adapter, and an antimicrobial coating. The antimicrobial coating is applied to at least a portion of the catheter adapter and comprises a base material that releases one or more antimicrobial agents when the antimicrobial coating is inserted into a patient's skin. The base material also provides a torsion-resistant catheter.
[007] In some embodiments, the antimicrobial coating may be positioned adjacent to the catheter adapter and / or may include an enlarged diameter portion. In some embodiments, the enlarged diameter portion is positioned adjacent to the catheter adapter.
[008] In some embodiments, the length of the antimicrobial lining can be configured, so that the distal end of the antimicrobial lining is positioned close to an inner layer of a vein, when the catheter is inserted into the vein. In some embodiments, this length can be between 7 mm and 12 mm.
[009] In some embodiments, the base material can be hydroscopic to increase the release of antimicrobial agents, when the antimicrobial coating is positioned inside the patient's skin. In some embodiments, the base material may be a UV-cured acrylate-urethane or a thermally-cured polyurethane. In some embodiments, the base material may have a hardness that slightly exceeds the hardness of the catheter.
[010] In some embodiments, the vascular access device may also include an antimicrobial lubricant that is applied to the catheter. In some embodiments, the antimicrobial lubricant can be applied to a portion of the catheter that does not include the antimicrobial coating.
[011] In another embodiment, the present invention is implemented as a vascular access device. The vascular access device includes a catheter adapter, a catheter that extends distally from the catheter adapter, and an antimicrobial coating. The antimicrobial coating extends from the catheter adapter to a distal end of the catheter and has an enlarged diameter portion adjacent to the catheter adapter.
[012] In another embodiment, the present invention is implemented as a catheter comprising an antimicrobial coating applied to a portion of the catheter. The antimicrobial coating has a proximal end and a distal end. The proximal end comprises a portion of increased diameter. The antimicrobial coating also comprises a base material that releases one or more antimicrobial agents, when the antimicrobial coating is positioned within a patient's skin.
[013] This Summary is provided to introduce a selection of concepts in a simplified form which is further described below in the Detailed Description. This Summary is not intended to identify the main characteristics or essential characteristics of the claimed subject.
[014] The additional features and advantages of the invention will be presented in the description that follows, and in part will be obvious from the description, or can be learned by practicing the invention. The characteristics and advantages of the invention can be realized and obtained by means of the instruments and combinations particularly highlighted in the appended claims. These and other features of the present invention will become more fully apparent from the following description and the appended claims, or can be learned from the practice of the invention as set out below. BRIEF DESCRIPTION OF THE DRAWINGS
[015] In order to describe the manner in which the above and other advantages and features of the invention can be obtained, a more particular description of the invention briefly described above will be made with reference to specific embodiments thereof which are illustrated in the attached drawings. Understanding that these drawings describe only typical modalities of the invention and should therefore not be considered as limiting its scope, the invention will be described and explained with additional specificity and detail through the use of the attached drawings in which:
[016] Figure 1 is a perspective view of a vascular access device that includes an antimicrobial coating that functions as a torsion resistant feature on the catheter.
[017] Figure 1A is a perspective view of the vascular access device of Figure 1 showing the antimicrobial coating along a length of the catheter.
[018] Figure 2 illustrates a cross-sectional view of a portion of a vascular access device.
[019] Figure 3 illustrates a cross-sectional view of the vascular access device of Figure 2, when it was inserted into a patient's vasculature.
[020] Figure 3A is a detailed cross-sectional view of the antimicrobial coating in contact with dermal layers of the skin, the primary source of resident bacteria.
[021] Figure 4 is a cross-sectional view of a vascular access device with the addition of an antimicrobial lubricant over a distal portion of the catheter.
[022] Figure 5 is a cross-sectional view of a vascular access device, when the antimicrobial coating extends along the entire length of the catheter. DETAILED DESCRIPTION OF THE INVENTION
[023] Figure 1 illustrates an example of the vascular access device 100 that includes an antimicrobial coating 103 according to one or more embodiments of the invention. The vascular access device 100 includes a catheter adapter 102 and a catheter 101 that extend distally from the catheter adapter. Although the vascular access device 100 is shown to include an extension tube, a vascular access device according to the present invention need not include extension tubes. In addition, the vascular access device 100 is an example of a peripheral intravenous catheter. However, an antimicrobial coating according to the present invention can be applied to other types of catheters including central venous catheters and peripherally inserted central catheters. In summary, any device that includes a flexible component that is inserted into a patient's vasculature can include an antimicrobial coating on the component, according to one or more embodiments of the present invention.
[024] The antimicrobial coating can comprise any material that has antipathogenic properties that can be applied to the surface of a catheter and that is sufficiently rigid to minimize the likelihood of the catheter becoming twisted when it is bent. For example, in some embodiments, the antimicrobial coating may comprise a matrix of base material and one or more antimicrobial agents. In some embodiments, the base material matrix may be a hydrophilic, UV-curable material that contains an antimicrobial agent with controlled release characteristics (elution). Alternatively, a base material can be coated with an antimicrobial coating from which an antimicrobial agent will elute when subjected to a fluid.
[025] For example, the base material, in some embodiments, can be a UV curing matrix of decalcified water, such as UV cured acrylate-urethanes, or thermally cured polyurethanes. Softened water materials can be preferred in many implementations over non-softened materials, such as materials that become more flexible when inserted into the patient and exposed to the fluid. Catheters are often formed from such softened water materials. Therefore, using an antimicrobial coating that also consists of a softened water material can match the properties of the coating to the catheter to minimize any negative impact that the coating may have on the performance of the catheter and on patient comfort. For example, in some embodiments, the hardness of the antimicrobial coating may only slightly exceed that of the catheter. This increased hardness minimizes the probability of the catheter being twisted, while minimally affecting patient comfort during catheter use because the catheter remains substantially elastic.
[026] Examples of materials that could be used to form the antimicrobial coating of the present invention include those described in U.S. Patent No. 8,512,294 entitled Vascular Access Device Antimicrobial Materials and Solutions; U.S. Patent Application No .: 12 / 397,760 entitled Antimicrobial Compositions; U.S. Patent Application No .: 12 / 476,997 entitled Antimicrobial Coating Compositions; U.S. Patent Application No .: 12 / 490,235 entitled Systems and Methods for Applying an Antimicrobial Coating to a Medical Device; and U.S. Patent Application No .: 12 / 831,880 entitled Antimicrobial Coating for Dermally Invasive Devices. Each of these patent documents is incorporated herein by reference.
[027] In a particular embodiment, the antimicrobial agent used to form the antimicrobial coating can be chlorhexidine including chlorhexidine diacetate (CHA) and / or chlorhexidine gluconate (CHG). However, any other antimicrobial agent that elutes from a base material or a coating on a base material could be used.
[028] Figure 1A illustrates a detailed view of catheter 101 and antimicrobial lining 103. As shown, antimicrobial lining 103 can extend from catheter adapter 102 along a portion of catheter 101. In this example, the antimicrobial lining 103 extends over about half the length of catheter 101. However, in some embodiments, the antimicrobial coating 103 may extend over a greater or lesser length of catheter 101, including the extension to the distal tip.
[029] As best seen in Figure 1A, the proximal end of the antimicrobial lining 103 may have a diameter that increases for catheter adapter 102. Catheter 101 is more susceptible to twisting as it exits from the catheter adapter. catheter 102. Consequently, increasing the diameter of the antimicrobial coating 103 for catheter adapter 102 provides additional torsion resistance where otherwise torsions would be more likely to occur. In some embodiments, as shown in Figure 1A, the increase in the diameter of the antimicrobial coating 103 can be gradually increased to the point where the antimicrobial coating has the same diameter as the nose of the catheter adapter 102.
[030] Although in Figures 1 and 1A the antimicrobial coating 103 is shown to extend only to the catheter adapter 102, in some embodiments, the antimicrobial coating may extend proximally over a portion of the catheter adapter. In addition, in some embodiments, the diameter of the antimicrobial coating at the point where it meets the catheter adapter can be configured to be smaller than the diameter of the catheter adapter at that point. In addition, in some embodiments, instead of having a diameter gradually increasing, the diameter may increase from a smaller diameter to a larger diameter some distance from the catheter adapter. In this way, the present invention encompasses many different types of increases in the diameter of the antimicrobial coating as the coating approaches the catheter adapter.
[031] Figure 1A also shows that the diameter of the antimicrobial coating 103 decreases to a minimum amount at the distal end of the coating. Having a minimum diameter at the distal end of the lining can minimize any discomfort caused to the patient when catheter 101 is inserted.
[032] Figure 1A also illustrates that, in some embodiments, an antimicrobial lubricant 104 can be applied to any portion of the catheter that does not include the antimicrobial coating. However, the present invention encompasses modalities, where only one antimicrobial coating is applied to a catheter regardless of whether the antimicrobial coating extends only over a portion of the length of the catheter.
[033] Figure 2 provides a cross-sectional view of the vascular access device 100 to better illustrate the increase in the diameter of the antimicrobial coating 103. As shown, for a distal end of the antimicrobial coating 103, the diameter of the coating is minimal. In some embodiments, the diameter at this distal end can be between 10 and 100 microns. Then, as the antimicrobial coating 103 approaches the catheter adapter 102, the diameter gradually increases to form an enlarged diameter portion 103a. The increased diameter portion 103a can provide an increased torsion resistance to a catheter as it exits catheter adapter 102. For example, due to the increased diameter of portion 103a, the catheter is unlikely to bend sufficiently at the point where it it comes out of catheter adapter 102 to cause a twist. In other words, the enlarged diameter portion 103a will tend to cause the catheter 101 to bend more gradually as it exits the catheter adapter 102, instead of bending sharply at the exit point. Similarly, the other portions (smaller diameter) of the antimicrobial coating 103 can provide additional stiffness to catheter 101 to minimize the likelihood of any sharp folds that may result in twisting.
[034] Figure 3 illustrates how the antimicrobial coating 103 can provide resistance to torsion to a catheter 101. As shown, catheter adapter 102 is generally positioned flat on the patient's skin 300. Because of this, catheter 101 will be tilted down from the point where it exits the catheter adapter 102, at the point where it enters through the patient's skin 300. The antimicrobial coating 103 and, more particularly, the enlarged diameter portion 103a causes the catheter 101 bend more gradually between the insertion point and the catheter adapter 102 thereby minimizing the likelihood of twisting.
[035] Figure 3 also illustrates an example where the length of the antimicrobial lining 103 is configured, so that the lining extends through the dermal layers of the skin 300 and into the vein 301. In this way, antimicrobial agents can be released from the antimicrobial coating 103 directly to the dermal layers and at the insertion points on the skin 300 and vein 301. These sites, and particularly the dermal layers, are the primary source of bacteria that can enter the vein 301. For this reason, the length of the antimicrobial coating 103 can be configured to ensure that the antimicrobial agents are directed to these locations.
[036] Figure 3A provides a detailed view of a portion of Figure 3 to illustrate the dermal layers 302 of skin 300 where catheter 101 is inserted. As shown, antimicrobial coating 103 is of sufficient length to ensure that the coating is in contact with the dermal layers. Using an antimicrobial coating that elutes antimicrobial agents (for example, a coating that is hydroscopic), antimicrobial agents can be delivered to dermal layers (and surrounding areas) in a controlled manner to minimize the possibility of toxicity from the agents.
[037] As noted above, when an antimicrobial lubricant is used to provide antimicrobial protection to these dermal layers, there is an increased risk of toxicity because it is difficult to guarantee that antimicrobial agents will be located in the dermal layers and not introduced into the patient's vasculature in toxic levels. In contrast, by using an antimicrobial coating comprising a base material that elutes antimicrobial agents, antimicrobial agents can be accurately distributed to dermal layers 302 and released at a rate that provides long-term antimicrobial protection. In other words, the antimicrobial coating 103 can limit the total amount of a particular antimicrobial agent that elutes over the life of the device, and concentrate the agent in the area of maximum benefit.
[038] To ensure proper positioning of the antimicrobial coating 103 when the vascular access device 100 is used, the antimicrobial coating 103 can be configured to an appropriate length. For example, the depth of the tissue between the outer layers of the skin and the inner layers of the vein is usually between 3 mm and 6 mm. In addition, it is typical for 4 mm to 6 mm of the catheter to remain outside the skin. Therefore, in some embodiments, the length of the antimicrobial coating 103 can extend from 7 mm to 12 mm from the catheter adapter to ensure that the distal end of the coating is positioned at least, if not beyond, the inner layers of the vein.
[039] Of course, other lengths of antimicrobial coating can be used in other modalities. In summary, the length of the antimicrobial coating can be selected for a particular vascular access device based, at least partially, on the typical length of the catheter that remains outside the skin when the particular vascular access device is used. For example, many catheters include a line or other indication that identifies how the catheter depth should be inserted. In some embodiments, the length of the antimicrobial coating 103 may be based on the length of the catheter between the catheter adapter and this type of indication. Similarly, the length of the antimicrobial coating can also be based on distance, from the outer layers of the skin and the inner layers of a vein where the catheter will be inserted (that is, the length can be based on the intended location where the catheter will typically be inserted).
[040] The antimicrobial coating of the present invention can be particularly beneficial over a vascular access device that is used to draw blood. It is becoming more and more common to take blood samples through vascular access devices that were previously used mainly to inject fluids into the patient's vasculature. When fluids are being injected, there is less concern about torsion, because fluid pressure tends to open up any torsions that may otherwise occur in the catheter. However, when these same devices are used to draw blood, torsion is more likely due to the reduced pressures and flow rates used when drawing blood. The antimicrobial coating of the present invention can therefore be particularly beneficial in preventing sprains during blood withdrawal.
[041] Figure 4 illustrates an alternative embodiment of the vascular access device illustrated in Figure 3. Figure 4 differs from Figure 3, in which an antimicrobial lubricant 310 was applied to the portion of catheter 101 that does not include antimicrobial coating 103.0 antimicrobial lubricant 310, in some embodiments, may also extend at least partially over the antimicrobial lining 103. Antimicrobial lubricant 310 can provide lubrication to catheter 101 to assist insertion and may also provide additional antimicrobial protection along the insertion site. For example, as catheter 101 is inserted, antimicrobial lubricant 310 can rub over the dermal layers of the skin to provide immediate and concentrated antimicrobial protection. Then, the antimicrobial coating 103, once positioned within the dermal layers, can continue to provide antimicrobial protection in a controlled release and targeted manner. Antimicrobial lubricant 310 can also assist in preventing the formation of clots on and in catheter 101 and, in particular, in the distal opening or catheter openings 101.
[042] Figure 5 illustrates another alternative modality of the vascular access device illustrated in Figure 3. Figure 5 differs from Figure 3 in that the antimicrobial coating 103 extends to the distal end of the catheter 101. In these cases, an antimicrobial lubricant , although it is not represented, it can also be used.
[043] According to one or more embodiments of the invention, an antimicrobial coating can be applied to a vascular access device by delivering an uncured base material to the catheter adjacent to the catheter adapter. This base material can be applied while rotating the catheter slowly (for example, between 20 and 120 rpm). The catheter can continue to be rotated, while a dye is used to draw the base material over the desired length of the catheter. In some embodiments, a sample dye can be used. Then the coating can be cured. In some embodiments, the catheter can continue to be rotated while the coating is cured.
[044] The present invention can be realized in other specific forms without departing from its scope or essential characteristics. The described modalities should be considered in all aspects only as illustrative and not restrictive. The scope of the invention is therefore indicated by the appended claims instead of the previous description. All changes that are within the meaning and equivalence range of the claims must be included within its scope.

权利要求:
Claims (19)
[0001]
1.Vascular access device, CHARACTERIZED by the fact that it comprises: a catheter adapter; a catheter extending distally from the catheter adapter and comprising a material; and an antimicrobial coating applied to at least a portion of the catheter, the antimicrobial coating comprising a base material that releases one or more antimicrobial agents, when the antimicrobial coating is inserted into a patient's skin, where the material is cured by UV and has a greater hardness than the hardness of the catheter material to provide resistance to torsion to the catheter, where antimicrobial coating is uniform in thickness over a first portion of the catheter, where the antimicrobial coating increases in thickness over of a second portion of the catheter adjacent to the catheter adapter, where when the catheter is inserted into a patient's vein, the first portion is configured to be positioned at least on an inner layer of the vein and the second portion is configured to be arranged out of a patient's body at least close to the outer layers of the skin.
[0002]
2. Vascular access device according to claim 1, CHARACTERIZED by the fact that a distal end of the antimicrobial coating is positioned proximal to a distal end of the catheter.
[0003]
3.Vascular access device according to claim 1, CHARACTERIZED by the fact that the length of the antimicrobial coating is between 7 mm and 12 mm.
[0004]
4.Vascular access device, according to claim 1, CHARACTERIZED by the fact that the base material is hydroscopic.
[0005]
5.Vascular access device according to claim 1, CHARACTERIZED by the fact that the base material is UV-cured acrylate-urethane.
[0006]
6.Vascular access device according to claim 1, CHARACTERIZED by the fact that the thickness of the antimicrobial coating at a distal end of the antimicrobial coating is between 10 microns and 100 microns.
[0007]
7.Vascular access device, according to claim 1, CHARACTERIZED by the fact that it still comprises: an antimicrobial lubricant applied to the catheter.
[0008]
8.Vascular access device according to claim 7, CHARACTERIZED by the fact that the antimicrobial lubricant is applied to a portion of the catheter that does not include the antimicrobial coating.
[0009]
9.Vascular access device, according to claim 1, CHARACTERIZED by the fact that the length of the second portion is less than 6mm.
[0010]
10.Vascular access device, according to claim 1, CHARACTERIZED by the fact that the first portion is adjacent to the second portion.
[0011]
11.Vascular access device according to claim 1, CHARACTERIZED by the fact that the thickness of the antimicrobial coating gradually increases over the second portion of the catheter.
[0012]
12.Vascular access device according to claim 1, CHARACTERIZED by the fact that the thickness of the antimicrobial coating increases from a smaller diameter to a larger diameter at some point along the second portion of the catheter.
[0013]
13.Vascular access device according to claim 1, CHARACTERIZED by the fact that the antimicrobial coating extends beyond a distal end of the catheter adapter to only a portion of the catheter adapter.
[0014]
14.Vascular access device according to claim 1, CHARACTERIZED by the fact that the diameter of the antimicrobial coating at a point where the antimicrobial coating meets the catheter adapter is smaller than a diameter of the catheter adapter at the point.
[0015]
15.Vascular access device, CHARACTERIZED by the fact that it comprises: a catheter adapter; a catheter extending distally from the catheter adapter; and an antimicrobial coating on the catheter, the antimicrobial coating extending from the catheter adapter towards a distal end of the catheter, the antimicrobial coating comprising a base material that releases one or more antimicrobial agents, when the antimicrobial coating is inserted within a patient's skin, where the base material is cured in such a way that the base material provides increased catheter stiffness, the antimicrobial coating having an increased diameter portion adjacent to the catheter adapter, where the antimicrobial coating increases in thickness from a distal portion of the catheter to a proximal portion of the catheter near a distal end of the catheter adapter.
[0016]
16.Vascular access device according to claim 15, CHARACTERIZED by the fact that the antimicrobial coating has an excess hardness in relation to the hardness of the catheter.
[0017]
17.Vascular access device according to claim 15, CHARACTERIZED by the fact that a distal end of the antimicrobial coating is positioned at a length from the catheter adapter corresponding to a length of the catheter, which is intended to exist between an internal layer of a vein and the catheter adapter, when the catheter is inserted into the vein.
[0018]
18.Vascular access device, CHARACTERIZED by the fact that it comprises: an antimicrobial coating applied to a portion of the catheter, the antimicrobial coating having a proximal end and a distal end, in which the base material is cured in such a way that the material base provides increased catheter rigidity, where the antimicrobial coating is uniform in thickness over the first catheter portion, where the antimicrobial coating increases in thickness along the second catheter portion of the catheter adjacent to the catheter adapter, where a outer diameter of the antimicrobial coating at a proximal end of the second portion is equal to an outer diameter of a distal end of the catheter adapter.
[0019]
19.Vascular access device according to claim 18, CHARACTERIZED by the fact that the catheter is positioned inside the catheter adapter, so that the proximal end of the antimicrobial coating is positioned adjacent to the catheter adapter.

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引用文献:

公开号 | 申请日 | 公开日 | 申请人 | 专利标题

US1844023A|1929-01-02|1932-02-09|Cash A W Co|Hose clamp|

DE821629C|1950-09-07|1951-11-19|Karl Hummel|Hose, especially for hairdryers|

US3223629A|1963-05-13|1965-12-14|Shell Oil Co|Lubricant compositions|

US3352531A|1964-04-02|1967-11-14|Scovill Manufacturing Co|Check valve|

US3598127A|1968-06-06|1971-08-10|James G Wepsic|Catheter having antibacterial substance therein provided with means permitting slow release of said substance|

US3695921A|1970-09-09|1972-10-03|Nat Patent Dev Corp|Method of coating a catheter|

DE2104745A1|1971-02-02|1972-08-03|Schulz H|Back protection device|

US3867937A|1972-12-07|1975-02-25|Boris Schwartz|Flexible protective sheath for catheter|

US3986508A|1973-08-22|1976-10-19|Abcor, Inc.|Sterilizable, medical connector for blood processing|

US4068660A|1976-07-12|1978-01-17|Deseret Pharmaceutical Co., Inc.|Catheter placement assembly improvement|

US4170996A|1977-11-03|1979-10-16|Rehabilitation Institute Of Chicago|Catheterization unit|

US4280500A|1978-03-31|1981-07-28|Kazuaki Ono|Tubular flexible medical instrument|

DE2817102C2|1978-04-19|1985-01-24|Dr. Eduard Fresenius, Chemisch-pharmazeutische Industrie KG, 6380 Bad Homburg|Connector for plastic cannulas or venous catheters|

US4334551A|1979-04-30|1982-06-15|Becton Dickinson & Company|Connector|

US4359564A|1980-03-14|1982-11-16|Rohm & Haas Co.|Addition polymer of oligomeric polyesters of acrylic acid|

WO1982000413A1|1980-07-28|1982-02-18|Lab Abbott|Improved radiopaque medical tubing|

US4339336A|1981-03-23|1982-07-13|Texaco Inc.|Quaternary ammonium succinimide salt composition and lubricating oil containing same|

US4469835A|1981-06-05|1984-09-04|Baxter Travenol Laboratories, Inc.|Connector member adapted for ultraviolet antimicrobial irradiation|

NL8301342A|1982-04-28|1983-11-16|Wallace Ltd H G|CONNECTING DEVICE FOR USE WITH A MEDICAL DEVICE.|

US4469483A|1982-08-25|1984-09-04|Baxter Travenol Laboratories, Inc.|Radiopaque catheter|

US4449693A|1982-09-30|1984-05-22|Gereg Gordon A|Catheter check valve|

US4603152A|1982-11-05|1986-07-29|Baxter Travenol Laboratories, Inc.|Antimicrobial compositions|

US4677143A|1984-10-01|1987-06-30|Baxter Travenol Laboratories, Inc.|Antimicrobial compositions|

US4512766A|1982-12-08|1985-04-23|Whitman Medical Corporation|Catheter valve|

US4592920A|1983-05-20|1986-06-03|Baxter Travenol Laboratories, Inc.|Method for the production of an antimicrobial catheter|

US4716032A|1983-08-03|1987-12-29|Geoffrey J. Westfall|Aerosol spray composition for mastitis prevention|

WO1985001876A1|1983-10-24|1985-05-09|Lockley Services Pty. Ltd.|Foamable biocide composition|

US4585435A|1984-05-31|1986-04-29|The Telescope Folding Furniture Co., Inc.|Extension set for drug delivery|

US4584192A|1984-06-04|1986-04-22|Minnesota Mining & Manufacturing Company|Film-forming composition containing an antimicrobial agent and methods of use|

JPH027669B2|1984-09-13|1990-02-20|Terumo Corp|

CA1245931A|1984-09-21|1988-12-06|Sophia Pesotchinsky|Positionable tissue interfacing device for themanagement of percutaneous conduits|

DE3502594A1|1985-01-26|1986-07-31|Etablissement Dentaire Ivoclar, Schaan|X-RAY OPAQUE DENTAL MATERIAL|

US4642126A|1985-02-11|1987-02-10|Norton Company|Coated abrasives with rapidly curable adhesives and controllable curvature|

US4629743A|1985-05-20|1986-12-16|The B.F. Goodrich Company|Process for preparing high bulk density vinyl resins|

KR900006272B1|1985-07-24|1990-08-27|마쯔시다덴기산교 가부시기가이샤|Thermal dye transfer printing systems thermal printing sheets and dye receiving sheet|

DE3530349C1|1985-08-24|1987-04-02|Braun Melsungen Ag|Device for introducing liquids or cannulas, stylets and catheters into a body cavity|

US4781703A|1985-10-17|1988-11-01|Menlo Care, Inc.|Catheter assembly|

GB8527646D0|1985-11-08|1985-12-11|Cox J A|Devices for sampling drainage|

US4955890A|1986-01-16|1990-09-11|Vitaphore Corporation|Surgical skin incision device, percutaneous infection control kit and methods of use|

IL78826A|1986-05-19|1991-05-12|Yissum Res Dev Co|Precursor composition for the preparation of a biodegradable implant for the sustained release of an active material and such implants prepared therefrom|

US4895566A|1986-07-25|1990-01-23|C. R. Bard, Inc.|Coating medical devices with cationic antibiotics|

US4723948A|1986-11-12|1988-02-09|Pharmacia Nu Tech|Catheter attachment system|

GB8627808D0|1986-11-20|1986-12-17|Cox J A|Sampling liquids from human/animal body|

US6051609A|1997-09-09|2000-04-18|Tristrata Technology, Inc.|Additives enhancing the effect of therapeutic agents|

DE3800094C2|1987-01-14|1998-05-14|Ciba Geigy Ag|Process and hydrophobic preparation for combating cut parasites in plants|

US4805933A|1987-05-20|1989-02-21|Swisher Mower & Machine Co., Inc.|Hose end sleeve|

US20010018095A1|1987-07-17|2001-08-30|Shlenker Robin Renee Thill|Method of forming a membrant, especially a latex or polymer membrane, including multiple discrete layers|

US4798594A|1987-09-21|1989-01-17|Cordis Corporation|Medical instrument valve|

US4880414A|1987-12-31|1989-11-14|Pharmacia Nu Tech|Catheter attachment system|

US4842591A|1988-01-21|1989-06-27|Luther Ronald B|Connector with one-way septum valve, and assembly|

US5019096A|1988-02-11|1991-05-28|Trustees Of Columbia University In The City Of New York|Infection-resistant compositions, medical devices and surfaces and methods for preparing and using same|

DE3809127C1|1988-03-18|1989-04-13|B. Braun Melsungen Ag, 3508 Melsungen, De|

US4846812A|1988-03-22|1989-07-11|Menlo Care, Inc.|Softening catheter|

US5030665A|1988-04-08|1991-07-09|Becton, Dickinson And Company|Ultraviolet cured peelable film and method therefor|

US5013717A|1988-04-18|1991-05-07|Becton, Dickinson And Company|Blood compatible, lubricious article and composition and method therefor|

US5064416A|1988-05-26|1991-11-12|Newgard Kent W|Self-occluding intravascular cannula assembly|

US4874377A|1988-05-26|1989-10-17|Davis Newgard Revocable Family Living Trust|Self-occluding intravascular cannula assembly|

CA1331333C|1988-07-20|1994-08-09|Thomas M. Gentle|Antimicrobial antifoam compositions and methods|

US4950257A|1988-09-15|1990-08-21|Mallinckrodt, Inc.|Catheter introducer with flexible tip|

US4933178A|1988-10-07|1990-06-12|Biointerface Technologies, Inc.|Metal-based antimicrobial coating|

AT391814B|1988-11-22|1990-12-10|Hirnich Paul|CONNECTING PIECE FOR AN INFUSION DEVICE OD. DGL.|

US5129887A|1988-12-07|1992-07-14|Scimed Life Systems, Inc.|Adjustable manifold for dilatation catheter|

US4925668A|1989-01-18|1990-05-15|Becton, Dickinson And Company|Anti-infective and lubricious medical articles and method for their preparation|

DE3913392C2|1989-04-24|1991-03-14|Sterimed Gesellschaft Fuer Medizinischen Bedarf Mbh, 6600 Saarbruecken, De|

US4990357A|1989-05-04|1991-02-05|Becton, Dickinson And Company|Elastomeric segmented hydrophilic polyetherurethane based lubricious coatings|

US5226898A|1989-08-30|1993-07-13|The Kendall Company|Catheter adapter with strain relief|

NL8902307A|1989-09-14|1991-04-02|Cordis Europ|CATHETER.|

US5078703A|1989-10-13|1992-01-07|Abbott Laboratories|Catheter adapter and retainer|

US4976697A|1989-10-26|1990-12-11|Becton, Dickinson And Company|Catheter obturator with automatic feed and control|

US5098410A|1989-12-13|1992-03-24|Becton, Dickinson And Company|Adapter cap attachment|

US5053014A|1990-02-01|1991-10-01|Critikon, Inc.|Catheter with controlled valve|

US5041097A|1990-02-26|1991-08-20|Johnson Gerald W|Intravenous catheter fitting with protective end seal|

US5062836A|1990-03-14|1991-11-05|The Kendall Company|Placement device for a catheter and guide wire|

US5084023A|1990-03-22|1992-01-28|Critikon, Inc.|Bloodless catheter with self-shielding needle|

DE4011867A1|1990-04-12|1991-10-17|Herberts Gmbh|Conductive, radiation-cured coating materials - contain radiation-curable monomer oligomer and/or polymer, mica pigment coated with antimony doped tin oxide photoinitiators, etc.|

US5077352A|1990-04-23|1991-12-31|C. R. Bard, Inc.|Flexible lubricious organic coatings|

US5127905A|1990-05-02|1992-07-07|Critikon, Inc.|Stickless catheter with manual shut-off valve|

US5108374A|1990-05-02|1992-04-28|Critikon, Inc.|Stickless catheter with manual shut-off valve|

US5085645A|1990-08-15|1992-02-04|Becton, Dickinson And Company|Apparatus and method for a catheter adapter with valve|

US5154703A|1990-10-30|1992-10-13|Care Medical Devices, Inc.|Bloodless catheter|

US5330449A|1991-01-17|1994-07-19|Sherwood Medical Company|Catheter strain relief device|

US5290246A|1991-01-18|1994-03-01|Terumo Kabushiki Kaisha|Piercing needle|

US5098405A|1991-01-31|1992-03-24|Becton, Dickinson And Company|Apparatus and method for a side port cathether adapter with a one piece integral combination valve|

US5156596A|1991-02-04|1992-10-20|Menlo Care, Inc.|Catheter with changeable number of lumens|

US5773487A|1991-05-15|1998-06-30|Uv Coatings, Inc.|Finishing composition which is curable by UV light and method of using same|

US5242425A|1991-11-14|1993-09-07|Gish Biomedical, Inc.|Antiseptic catheter coupling septum|

CA2125167A1|1991-12-06|1993-06-10|North Shore University Hospital Research Corporation|Method of reducing medical device related infections|

US5944712A|1992-03-02|1999-08-31|Medtronic Ave, Inc.|Catheter size designation system|

US5217493A|1992-03-11|1993-06-08|Board Of Regents, The University Of Texas System|Antibacterial coated medical implants|

US5256145A|1992-03-17|1993-10-26|Scimed Life Systems, Inc.|Dilatation catheter strain relief assembly|

JP2666654B2|1992-04-01|1997-10-22|住友金属工業株式会社|How to apply water-soluble rust preventive oil to steel|

US5295969A|1992-04-27|1994-03-22|Cathco, Inc.|Vascular access device with air-tight blood containment capability|

TW227518B|1992-06-30|1994-08-01|Toa Gosei Chem Ind|

US5357636A|1992-06-30|1994-10-25|Dresdner Jr Karl P|Flexible protective medical gloves and methods for their use|

US5380301A|1992-07-10|1995-01-10|Sherwood Medical Company|Catheter/hub strain relief and method of manufacture thereof|

US5234410A|1992-10-23|1993-08-10|Vlv Associates|Catheter assembly|

US5458640A|1993-01-29|1995-10-17|Gerrone; Carmen J.|Cannula valve and seal system|

US5330435A|1993-04-08|1994-07-19|Vaillancourt Vincent L|Valve for a catheter assembly|

DE4311715C2|1993-04-08|1996-02-01|Fresenius Ag|Port cannula|

DE4312656C2|1993-04-19|1996-01-25|Beiersdorf Ag|Cooling cosmetic or dermatological compositions|

US5352378A|1993-05-27|1994-10-04|Minnesota Mining And Manufacturing Company|Nonflammable lubricious composition|

US5350363A|1993-06-14|1994-09-27|Cordis Corporation|Enhanced sheath valve|

US5657963A|1993-06-16|1997-08-19|United States Surgical Corporation|Seal assembly for accommodating introduction of surgical instruments|

JP2518794B2|1993-08-06|1996-07-31|本田技研工業株式会社|Hollow body with partition wall and manufacturing method thereof|

US5405338A|1993-08-19|1995-04-11|Cordis Corporation|Helically wound catheters|

US5547662A|1993-08-27|1996-08-20|Becton, Dickinson And Company|Preparation of a skin surface for a surgical procedure|

US5833674A|1993-08-27|1998-11-10|St. Paul Medical, Inc.|Needleless IV medical delivery system|

US5352205A|1993-09-16|1994-10-04|Lawrence Dales|Bloodless insertion catheter assembly|

JP2584597B2|1993-09-29|1997-02-26|ベクトン・ディッキンソン・アンド・カンパニー|Catheter introduction device with blood seal|

US5806831A|1993-10-13|1998-09-15|Paradis; Joseph R.|Control of fluid flow with internal cannula|

US5512199A|1993-11-02|1996-04-30|Becton Dickinson And Company|Hand wipe solution|

US5549577A|1993-12-29|1996-08-27|Ivac Corporation|Needleless connector|

US5536258A|1994-02-14|1996-07-16|Fresenius Usa, Inc.|Antibacterial medical tubing connector|

US5522804A|1994-02-15|1996-06-04|Lynn; Lawrence A.|Aspiration, mixing, and injection syringe|

US5405323A|1994-02-22|1995-04-11|Aeroquip Corporation|Catheter check valve assembly|

US5772606A|1994-03-04|1998-06-30|Kyoto Dai-Ichi Kagaku Co., Ltd.|Method of and apparatus for measuring uric components|

US5620434A|1994-03-14|1997-04-15|Brony; Seth K.|Medicine vial link for needleless syringes|

US5540661A|1994-05-03|1996-07-30|Medex, Inc.|Needleless valve having a covalently bonded lubricious coating|

US5487728A|1994-05-19|1996-01-30|Vaillancourt; Vincent L.|Connector assembly|

US5470319A|1994-06-20|1995-11-28|Critical Device Corporation|Needleless injection site|

CA2151774C|1994-06-27|1999-04-06|Minh Quang Hoang|Skin disinfecting formulations|

CA2154112C|1994-08-22|2000-09-26|Mohammad A. Khan|Water soluble lubricant for medical devices|

US6046143A|1994-08-22|2000-04-04|Becton Dickinson And Company|Water soluble lubricant for medical devices|

US5688747A|1994-08-22|1997-11-18|Becton Dickinson And Company|Water based lubricant solution|

US5589120A|1994-08-22|1996-12-31|Becton Dickinson And Company|Process of making a shaped tip on a catheter|

US5549566A|1994-10-27|1996-08-27|Abbott Laboratories|Valved intravenous fluid line infusion device|

DE4442352C1|1994-11-29|1995-12-21|Braun Melsungen Ag|Valve arrangement provided in connector for use e.g. with cannula|

WO1996016690A1|1994-11-29|1996-06-06|Becton, Dickinson And Company|A catheter having wall support to prevent collapse thereof|

US5520666A|1994-12-06|1996-05-28|Abbott Laboratories|Valved intravenous fluid line connector|

US5658253A|1995-02-21|1997-08-19|Abbott Laboratories|Stylet device for guiding an enteral feeding tube|

CA2169220A1|1995-03-16|1996-09-17|Greg L. Brimhall|Control forward introducer needle and catheter assembly|

US6413539B1|1996-10-31|2002-07-02|Poly-Med, Inc.|Hydrogel-forming, self-solvating absorbable polyester copolymers, and methods for use thereof|

US5575769A|1995-05-30|1996-11-19|Vaillancourt; Vincent L.|Cannula for a slit septum and a lock arrangement therefore|

US6273404B1|1995-06-05|2001-08-14|Scimed Life Systems, Inc.|Method of making monolithic hub and strain relief|

US5810768A|1995-06-07|1998-09-22|Icu Medical, Inc.|Medical connector|

GB9516658D0|1995-08-15|1995-10-18|Smiths Industries Plc|Medico-surgical devices|

DE69637829D1|1995-09-21|2009-03-12|Covidien Ag|Cone-shaped reinforced catheter|

US6503952B2|1995-11-13|2003-01-07|The Trustees Of Columbia University In The City Of New York|Triple antimicrobial composition|

EP0778337A3|1995-12-07|1997-06-25|Becton, Dickinson and Company|Waterborne lubricant for teflon products|

SG60166A1|1996-12-09|1999-02-22|Becton Dickinson Co|Waterborne lubricant for teflon products|

US5772640A|1996-01-05|1998-06-30|The Trustees Of Columbia University Of The City Of New York|Triclosan-containing medical devices|

US6120784A|1996-02-20|2000-09-19|Viro-Kote, Inc.|Anti-bacterial/anti-viral coatings, coating process and parameters thereof|

US6576633B1|1996-02-22|2003-06-10|The Dow Chemical Company|Stable liquid antimicrobial suspension compositions containing quarternaries prepared from hexamethylenetetramine and certain halohydrocarbons|

IT1285266B1|1996-02-26|1998-06-03|Borla Ind|CONNECTOR WITH PROTECTION VALVE FOR INFUSION / TRANSFUSION AND SIMILAR MEDICAL LINES.|

US5817069A|1996-02-28|1998-10-06|Vadus, Inc.|Valve assembly|

US5651772A|1996-02-28|1997-07-29|Aeroquip Corporation|Needle guard assembly|

US6042578A|1996-05-13|2000-03-28|Schneider Inc.|Catheter reinforcing braids|

JP3841232B2|1996-06-05|2006-11-01|Ｊｓｒ株式会社|Film forming composition|

US6273869B1|1996-06-13|2001-08-14|Vincent L. Vaillancourt|Valve connector|

US5718678A|1996-06-26|1998-02-17|Medical Components, Inc.|Multi-lumen coaxial catheter and method for making same|

US5738144A|1996-10-11|1998-04-14|Aeroquip Corporation|Luer connecting coupling|

US6883778B1|1996-11-18|2005-04-26|Nypro Inc.|Apparatus for reducing fluid drawback through a medical valve|

JP3752631B2|1996-11-18|2006-03-08|ナイプロ・インク|Swabable lure cone valve|

CN1187598A|1996-12-09|1998-07-15|贝克顿迪金森公司|Waterborne lubricant for teflon products|

EP0860213A3|1997-01-03|2002-10-16|Therapol SA|Bioactive coating on surfaces|

US5954698A|1997-01-08|1999-09-21|Vadus, Inc.|Catheter apparatus having valved catheter hub and needle protector|

US5967490A|1997-01-08|1999-10-19|Vadus, Inc.|Catheter hubs having a valve|

US6242526B1|1997-01-28|2001-06-05|Stepan Company|Antimicrobial polymer latexes derived from unsaturated quaternary ammonium compounds and antimicrobial coatings, sealants, adhesives and elastomers produced from such latexes|

US6084005A|1997-02-24|2000-07-04|Kuraray Co., Ltd.|Antimicrobial caries-detecting composition|

US5763412A|1997-04-08|1998-06-09|Becton Dickinson And Company|Film-forming composition containing chlorhexidine gluconate|

US5951519A|1997-04-25|1999-09-14|Dsu Medical Corporation|Aseptic female connector|

US5911710A|1997-05-02|1999-06-15|Schneider/Namic|Medical insertion device with hemostatic valve|

US6050978A|1997-05-09|2000-04-18|Becton Dickinson And Company|Needleless valve connector|

US5957898A|1997-05-20|1999-09-28|Baxter International Inc.|Needleless connector|

DE19721703A1|1997-05-23|1998-11-26|Angiomed Ag|Catheter system with high kink resistance|

US5843046A|1997-05-29|1998-12-01|Paul J. Motisi|Catheter apparatus|

US5997562A|1997-06-13|1999-12-07|Percusurge, Inc.|Medical wire introducer and balloon protective sheath|

DK0991702T3|1997-06-20|2001-12-03|Coloplast As|Hydrophilic coating|

US6110483A|1997-06-23|2000-08-29|Sts Biopolymers, Inc.|Adherent, flexible hydrogel and medicated coatings|

US6082490A|1997-07-15|2000-07-04|Rowland; Chris W.|Modular anechoic panel system and method|

DE29712676U1|1997-07-17|1997-11-13|Rycyk Manfred|Kink protection for catheters|

US6117108A|1997-08-20|2000-09-12|Braun Melsungen Ag|Spring clip safety IV catheter|

US8187278B2|1998-08-25|2012-05-29|Advanced Photodynamic Technologies, Inc.|Photodynamic cellular and acellular organism eradication utilizing a photosensitive material and benzalkonium chloride|

US6165168A|1997-09-02|2000-12-26|Russo; Ronald D.|Closed system adapter for catheters|

US6153187A|1997-09-02|2000-11-28|Insight Strategy & Marketing Ltd.|Use of glycosaminoglycans degrading enzymes for management of airway associated diseases|

US6358230B1|1997-10-01|2002-03-19|Scimed Life Systems, Inc.|Percutaneous catheter with slip hub|

US6217566B1|1997-10-02|2001-04-17|Target Therapeutics, Inc.|Peripheral vascular delivery catheter|

US6048338A|1997-10-15|2000-04-11|Scimed Life Systems, Inc.|Catheter with spiral cut transition member|

US6830745B1|1997-10-16|2004-12-14|Pharmacal Biotechnologies, Llc|Compositions for treating biofilm|

US20020037260A1|1997-10-16|2002-03-28|Budny John A.|Compositions for treating biofilm|

EP1023036B1|1997-10-18|2002-01-09|DDG Dental Devices GmbH|Disinfecting agent|

WO1999032168A1|1997-12-22|1999-07-01|Becton Dickinson And Company|A material for use in medical devices with a self-replenishing antimicrobial and/or lubricious surface|

NL1007997C2|1998-01-09|1999-07-12|Cordis Europ|Device for inserting an elongated medical device.|

US6127320A|1998-01-19|2000-10-03|University Of Cincinnati|Methods and compositions for increasing lubricity of rubber surfaces|

US6022551A|1998-01-20|2000-02-08|Ethicon, Inc.|Antimicrobial composition|

US20020022660A1|1998-01-20|2002-02-21|Hanuman B. Jampani|Deep penetrating antimicrobial compositions|

US6068622A|1998-02-10|2000-05-30|Medtronic Inc.|Single piece hub/strain relief that can be injection molded over a shaft|

WO1999042080A2|1998-02-19|1999-08-26|Oraceutical, Llc|Curable compositions with antimicrobial properties|

WO1999043971A1|1998-02-26|1999-09-02|Fillmore David J|Back flush valve for one-way flush of drainage catheters|

US6074379A|1998-03-06|2000-06-13|Sherwood Services Ag|Catheter strain relief device|

US6077244A|1998-04-30|2000-06-20|Mdc Investment Holdings, Inc.|Catheter insertion device with retractable needle|

CN100471535C|1998-05-29|2009-03-25|劳伦斯A·林恩|Luer receiver and method for fluid transfer|

WO2001039826A1|1998-06-03|2001-06-07|Nippon Sherwood Medical Industries Ltd.|Medical cock|

US6332874B1|1998-08-28|2001-12-25|C.R. Bard, Inc.|Coupling and stabilization system for proximal end of catheter|

US6228060B1|1998-09-02|2001-05-08|Becton, Dickinson And Company|Blood seal having a spring-biased septum|

US6726899B2|1998-09-24|2004-04-27|Advantage Dental Products, Inc.|Calcified tissue facing preparation containing antimicrobial agent|

US6299980B1|1998-09-29|2001-10-09|Medtronic Ave, Inc.|One step lubricious coating|

DE19848886C2|1998-10-23|2000-11-16|Heraeus Kulzer Gmbh & Co Kg|Light-polymerizable one-component dental material|

US6102890A|1998-10-23|2000-08-15|Scimed Life Systems, Inc.|Catheter having improved proximal shaft design|

US6344218B1|1998-11-23|2002-02-05|The Procter & Gamble Company|Skin deodorizing and santizing compositions|

AU2042200A|1998-12-07|2000-06-26|Baylor College Of Medicine|Preventing and removing biofilm from the surface of medical devices|

US6228073B1|1998-12-15|2001-05-08|Medtronic, Inc.|Angiography luer hub having wings proximal to the plurality of grips and strain relief|

JP2000178475A|1998-12-15|2000-06-27|Nisseki Kk|Antimicrobial deodorizing coating agent|

US6331176B1|1999-03-11|2001-12-18|Advanced Cardiovascular Systems, Inc.|Bleed back control assembly and method|

JP3824120B2|1999-03-18|2006-09-20|新東工業株式会社|Photopolymerizable monomer composition having antibacterial properties, and solvent-free ultraviolet and electron beam curable resin compositions having antibacterial properties|

US6224579B1|1999-03-31|2001-05-01|The Trustees Of Columbia University In The City Of New York|Triclosan and silver compound containing medical devices|

US6156373A|1999-05-03|2000-12-05|Scimed Life Systems, Inc.|Medical device coating methods and devices|

US6544214B1|1999-05-25|2003-04-08|Dsu Medical Corporation|Subcutaneous access needle and method|

WO2000074743A1|1999-06-04|2000-12-14|Oxibio, Inc.|Anti-infective medical device and production method|

EP1068876B1|1999-07-16|2004-01-14|Terumo Kabushiki Kaisha|Catheter and method of manufacturing the same|

US6706022B1|1999-07-27|2004-03-16|Alaris Medical Systems, Inc.|Needleless medical connector with expandable valve mechanism|

CA2380907C|1999-08-12|2009-12-08|Lawrence A. Lynn|Luer receiving vascular access system|

US7384895B2|1999-08-16|2008-06-10|Ecolab Inc.|Conveyor lubricant, passivation of a thermoplastic container to stress cracking and thermoplastic stress crack inhibitor|

JP2001072438A|1999-08-31|2001-03-21|Wako Kagaku Kogyo Kk|Antimicrobial processed flat glass material|

JP3935292B2|1999-09-16|2007-06-20|テルモ株式会社|connector|

US6326417B1|1999-10-21|2001-12-04|Jeneric/Pentron Incorporated|Anti-microbial dental compositions and method|

US6353041B1|1999-10-22|2002-03-05|Kerr Corporation|Dental compositions|

US6310013B1|1999-10-27|2001-10-30|Ecolab Inc.|Lubricant compositions having antimicrobial properties and methods for manufacturing and using lubricant compositions having antimicrobial properties|

US6440488B2|1999-12-03|2002-08-27|Ep Medsystems, Inc.|Flexible electrode catheter and process for manufacturing the same|

AT253082T|1999-12-08|2003-11-15|Ciba Sc Holding Ag|NEW PHOTOINITIATOR SYSTEM MADE OF PHOSPHINOXIDE COMPOUNDS AND LITTLE COLORED CURABLE COMPOSITIONS|

US7179849B2|1999-12-15|2007-02-20|C. R. Bard, Inc.|Antimicrobial compositions containing colloids of oligodynamic metals|

FR2802432B1|1999-12-16|2002-03-08|Vygon|AUTOMATIC SHUTTER CONNECTOR FOR CONNECTING A LIQUID INJECTION HEAD TO AN INJECTION OUTPUT|

US6579539B2|1999-12-22|2003-06-17|C. R. Bard, Inc.|Dual mode antimicrobial compositions|

US6575959B1|1999-12-27|2003-06-10|Scimed Life Systems, Inc.|Catheter incorporating an insert molded hub and method of manufacturing|

CA2395610A1|1999-12-30|2001-07-12|University Of Louisville Research Foundation, Inc.|Methods and compositions for inhibiting adhesion by microorganisms|

AT548016T|2000-04-03|2012-03-15|Chx Technologies Inc|USE OF CHLORHEXIDINE FOR THE PREVENTION OF ROOT CARIES|

US6599696B2|2000-04-17|2003-07-29|University Technologies International, Inc.|Effects of materials and surface coatings on encrustation and biofilm formation|

US6861060B1|2000-04-21|2005-03-01|Elena Luriya|Personal care formulations|

US6559176B1|2000-05-10|2003-05-06|Princeton University|Compounds and methods for regulating bacterial growth and pathogenesis|

US6575958B1|2000-05-23|2003-06-10|Advanced Cardiovascular Systems, Inc.|Catheter with improved transition|

DE60137334D1|2000-06-09|2009-02-26|Baylor College Medicine|Combination of Antimicrobial Agents and Bacterial Interference for Transferring Medical Devices|

EP1164171A3|2000-06-12|2002-04-24|General Electric Company|Silicone compositions|

EP1289473A1|2000-06-13|2003-03-12|Dentsply International, Inc.|Low shrinking polymerizable dental material|

US6699221B2|2000-06-15|2004-03-02|Vincent L. Vaillancourt|Bloodless catheter|

WO2001098214A1|2000-06-19|2001-12-27|Novozymes Biotech, Inc.|Methods for eliminating the formation of biofilm|

AT323517T|2000-08-15|2006-05-15|Surmodics Inc|MATRIX FOR THE ADMINISTRATION OF MEDICINAL PRODUCTS|

EP1197242A1|2000-10-13|2002-04-17|Arrabona Medical KFT.|Indwelling venous cannula|

US6663614B1|2000-11-06|2003-12-16|Advanced Cardiovascular Systems, Inc.|Catheter shaft having variable thickness layers and method of making|

US7329412B2|2000-12-22|2008-02-12|The Trustees Of Columbia University In The City Of New York|Antimicrobial medical devices containing chlorhexidine free base and salt|

US6893456B2|2000-12-22|2005-05-17|Advanced Cardiovascular Systems, Inc.|Catheter and method for making the same|

US6814085B2|2000-12-29|2004-11-09|Steven J. Brattesani|Dental floss with usage identification capability|

KR100405030B1|2001-02-10|2003-11-10|주식회사 유레이|New UV-curing antibacterial agents|

DE60201889T2|2001-02-28|2006-04-06|Covalon Technologies Inc., , Mississauga|METHOD FOR PRODUCING ANTIMICROBIAL POLYMER SURFACES|

JP4996015B2|2001-03-12|2012-08-08|メディキット株式会社|Indwelling catheter|

JP3730529B2|2001-03-27|2006-01-05|日本ペイント株式会社|Method and apparatus for coating porous material|

FR2823113B1|2001-04-06|2005-12-16|Oreal|ANTI-WRINKLE COSMETIC COMPOSITION WITH IMMEDIATE EFFECT BASED ON AQUEOUS DISPERSION OF AT LEAST ONE MINERAL LOAD|

WO2002085386A2|2001-04-23|2002-10-31|Nucryst Pharmaceuticals Corp.|Medicament containing a metal such as silver, gold, platinum or palladium as an antimicrobial agent and their use to induce apoptosis in cancerous tissue|

JP4116447B2|2001-05-01|2008-07-09|エイ．ブイ．トップチーブインスティテュートオブペトロケミカルシンセシス|Hydrogel composition|

US6506181B2|2001-05-25|2003-01-14|Becton, Dickinson And Company|Catheter having a low drag septum|

US6719727B2|2001-05-25|2004-04-13|Becton Dickinson And Company|Catheter having a wing with a stiffening member therein|

US6579221B1|2001-05-31|2003-06-17|Advanced Cardiovascular Systems, Inc.|Proximal catheter shaft design and catheters incorporating the proximal shaft design|

FR2826292B1|2001-06-22|2004-01-23|Rhodia Chimie Sa|OIL-IN-OIL EMULSIONS COMPRISING A SILICONE, DISPERSIONS OF SUCH EMULSIONS AND USE THEREOF|

US20030023208A1|2001-07-24|2003-01-30|Osypka Thomas P.|Apparatus for vascular access|

WO2003011821A2|2001-07-31|2003-02-13|Board Of Regents The University Of Texas System|Use of cyclic heptapeptides for the inhibition of biofilm formation|

DE10139574A1|2001-08-10|2003-02-20|Creavis Tech & Innovation Gmbh|Maintaining the lotus effect by preventing microbial growth on self-cleaning surfaces|

US7004934B2|2001-09-06|2006-02-28|Vaillancourt Vincent L|Closed system connector assembly|

DE10144531B4|2001-09-11|2006-01-19|Henkel Kgaa|UV-curable anti-fingerprint coatings, methods for coating and using a solvent-free coating agent|

WO2003022333A1|2001-09-13|2003-03-20|Cheng Gordon C|Personal urine management system for human males|

CA2460968C|2001-10-10|2009-11-03|Microban Products Company|Antimicrobial radiation curable coating|

US6846846B2|2001-10-23|2005-01-25|The Trustees Of Columbia University In The City Of New York|Gentle-acting skin disinfectants|

WO2003039529A1|2001-11-07|2003-05-15|4Sc A.G.|Selective antibacterial agents|

KR20050044418A|2001-11-13|2005-05-12|벡톤 디킨슨 앤드 컴퍼니|Spray dry process for applying anticoagulant on a syringe barrel|

BR0307066A|2002-01-22|2004-12-28|Upjohn Co|Infection Resistant Medical Device|

US20030144362A1|2002-01-28|2003-07-31|Utterberg David S.|High viscosity antibacterials for cannulae|

US20060024372A1|2004-07-29|2006-02-02|Utterberg David S|High viscosity antibacterials|

US7361719B2|2002-01-31|2008-04-22|Micro Science Tech Co., Ltd.|Monomer with anti-microbial character, polymer using the same, and manufacturing method thereof|

US6887270B2|2002-02-08|2005-05-03|Boston Scientific Scimed, Inc.|Implantable or insertable medical device resistant to microbial growth and biofilm formation|

DE60321773D1|2002-03-14|2008-08-07|Ash Access Technology Inc|MEDICAL DEVICES WITH ANTIBACTERIAL PROPERTIES|

NO320324B1|2002-03-26|2005-11-21|Jotun As|Polymers and monomers and their use as well as processes for preparing polymers and antifouling paints containing polymers|

CA2476288A1|2002-03-26|2003-10-09|Biosynexus Incorporated|Enzyme disruption of bacterial biofilms|

CN101461982B|2002-04-01|2012-06-27|Nd合伙人股份有限公司|Device for overcoming infection contamination in tissue bag surrounding implantation instrument|

AU2003225073A1|2002-04-18|2003-11-03|The University Of Iowa Research Foundation|Methods of inhibiting and treating bacterial biofilms by metal chelators|

US20040147671A1|2002-05-15|2004-07-29|Richard Milic|Decorative coating composition for solid substrates|

JP2003342402A|2002-05-27|2003-12-03|Mitsubishi Rayon Co Ltd|Antimicrobial resin molding having scratch resistance and production method therefor|

US6924325B2|2002-06-21|2005-08-02|Kerr Corporation|Silver-containing dental composition|

JP3808806B2|2002-06-26|2006-08-16|メディキット株式会社|Indwelling needle|

DE20210394U1|2002-07-04|2002-09-12|Braun Melsungen Ag|catheter introducer|

JP2004043669A|2002-07-12|2004-02-12|Dainippon Toryo Co Ltd|Toning method for powdery coating material|

US20040013574A1|2002-07-18|2004-01-22|Becton, Dickinson And Company|Specimen collection tube assembly with differentiated components|

US6916483B2|2002-07-22|2005-07-12|Biodynamics, Llc|Bioabsorbable plugs containing drugs|

US6971813B2|2002-09-27|2005-12-06|Labcoat, Ltd.|Contact coating of prostheses|

KR100917010B1|2002-11-27|2009-09-10|삼성전자주식회사|Method and apparatus for forming alignment film|

US20040115477A1|2002-12-12|2004-06-17|Bruce Nesbitt|Coating reinforcing underlayment and method of manufacturing same|

FR2849444B1|2002-12-30|2006-07-28|Rhodia Chimie Sa|PROCESS FOR PREPARING A SUSPENSION OF SILICA IN A SILICONE SUBSTANCE POSSIBLY CROSS-LINKABLE|

US7347839B2|2003-02-12|2008-03-25|Nipro Corporation|Indwelling catheter|

WO2004071568A1|2003-02-12|2004-08-26|Unomedical A/S|A medical connector and a method of injection moulding such a connector|

CN1247712C|2003-03-03|2006-03-29|珠海东诚化工有限公司|Visible light cured metal paint|

JP2004305466A|2003-04-08|2004-11-04|Nipro Corp|Medical connector set and catheter set for dwelling using the same|

US7306580B2|2003-04-16|2007-12-11|Cook Incorporated|Medical device with therapeutic agents|

US7195615B2|2003-05-14|2007-03-27|Boston Scientific Scimed, Inc.|System for providing a medical device with anti-microbial properties|

DK1644024T3|2003-06-06|2019-10-07|Univ Texas|ANTIMICROBIAL RINSE SOLUTIONS|

US7520489B2|2003-06-17|2009-04-21|Filtertek Inc.|Fluid handling device and method of making same|

JP2005028209A|2003-07-07|2005-02-03|Dainippon Ink & Chem Inc|Antibacterial, mildew-proofing cured-film and formation method therefor|

US8454566B2|2003-07-10|2013-06-04|Medtronic Minimed, Inc.|Methods and compositions for the inhibition of biofilms on medical devices|

AU2004258899B2|2003-07-17|2009-09-03|The Trustees Of Columbia University In The City Of New York|Antimicrobial compositons containing synergistic combinations of quaternary ammonium compounds and essential oils and/or constituents thereof|

US8043632B2|2003-08-18|2011-10-25|E. I. Du Pont De Nemours And Company|Process for making antimicrobial articles by reacting chitosan with amino-reactive polymer surfaces|

US7470254B2|2003-08-18|2008-12-30|Medical Components, Inc.|Needle with sealing valve|

US20050048005A1|2003-08-26|2005-03-03|Stockel Richard F.|Antimicrobial compositions for dental applications|

US7381751B2|2003-08-26|2008-06-03|Shantha Sarangapani|Antimicrobial composition for medical articles|

US20050059731A1|2003-09-16|2005-03-17|Ceramoptec Industries, Inc.|Erythrosin-based antimicrobial photodynamic therapy compound and its use|

US7762977B2|2003-10-08|2010-07-27|Hemosphere, Inc.|Device and method for vascular access|

US20070000407A1|2003-10-09|2007-01-04|York International Corporation|Nano composite photocatalytic coating|

WO2005037338A1|2003-10-14|2005-04-28|Cook Incorporated|Hydrophilic coated medical device|

US7635358B2|2003-10-15|2009-12-22|Boston Scientific Scimed, Inc.|Medical device having anti-microbial properties and a false lumen and method of making the same|

JP4849891B2|2003-11-05|2012-01-11|イビデン株式会社|Manufacturing method of honeycomb structure|

US20050124970A1|2003-12-05|2005-06-09|Medical Components, Inc.|Luer cap with antibacterial property|

US20050148928A1|2003-12-31|2005-07-07|Medtronic Minimed, Inc.|Multiple layer tubing and method of making same|

US20050147525A1|2004-01-06|2005-07-07|Bousquet Gerald G.|Sanitized tubing termination method and assembly|

US7074839B2|2004-03-01|2006-07-11|3M Innovative Properties Company|Crosslinkable hydrophilic materials from reactive oligomers having pendent photoinitiator groups|

US7594910B2|2004-03-18|2009-09-29|C. R. Bard, Inc.|Catheter connector|

US7594911B2|2004-03-18|2009-09-29|C. R. Bard, Inc.|Connector system for a proximally trimmable catheter|

US7144992B2|2004-04-01|2006-12-05|Kane Biotech Inc.|Synergistic antimicrobial compositions and methods for reducing biofilm formation|

US8414547B2|2004-04-29|2013-04-09|C. R. Bard, Inc.|Modulating agents for antimicrobial coatings|

US7232540B2|2004-05-02|2007-06-19|Ashland Licensing And Intellectual Property Llc|Radiation-curable coatings for plastic substrates from multifunctional acrylate oligomers|

US20050261582A1|2004-05-18|2005-11-24|Matthew Becker|Intracorporeal probe with disposable probe body|

PL1786490T3|2004-07-21|2012-07-31|Animas Corp|Method and system for providing an infusion device interface|

GB0417350D0|2004-08-04|2004-09-08|Incobar Ltd|Urinary products|

DE102004039409A1|2004-08-13|2006-02-23|Holmenkol Sport-Technologies Gmbh & Co. Kg|Lubricant for sports equipment|

US7268165B2|2004-08-20|2007-09-11|Steris Inc.|Enhanced activity alcohol-based antimicrobial compositions|

US9028852B2|2004-09-07|2015-05-12|3M Innovative Properties Company|Cationic antiseptic compositions and methods of use|

WO2006088288A1|2005-02-19|2006-08-24|Won-Dong Yang|Medical needles having antibacterial and painless function|

US8263102B2|2004-09-28|2012-09-11|Atrium Medical Corporation|Drug delivery coating for use with a stent|

JP2006102254A|2004-10-06|2006-04-20|Nippon Sherwood Medical Industries Ltd|Connecting structure of infusion line and connector provided with connecting structure|

AT514491T|2004-11-29|2011-07-15|Dsm Ip Assets Bv|METHOD FOR REDUCING THE AMOUNT OF MIGRATABLE COMPONENTS OF POLYMER COATINGS|

US7608082B2|2005-01-06|2009-10-27|Tyco Healthcare Group Lp|Surgical seal for use in a surgical access apparatus|

AT449127T|2005-01-17|2009-12-15|Biomodics|PROCESS FOR COATING A POLYMER SURFACE WITH A POLYMERIC COATING AND OBJECT, CONTAINING A POLYMER-COATED POLYMER|

US7749529B2|2005-02-08|2010-07-06|Ash Access Technology, Inc.|Catheter lock solution comprising citrate and a paraben|

WO2006085331A2|2005-02-14|2006-08-17|Flexicath Ltd.|Method and apparatus for inserting a catheter device|

US7498367B2|2005-02-21|2009-03-03|Kerr Corporation|Acid-tolerant dental composition|

EP1898900B1|2005-03-10|2011-06-08|3M Innovative Properties Company|Antimicrobial compositions comprising esters ofhydroxycarboxylic acids|

AU2006223137A1|2005-03-10|2006-09-21|3M Innovative Properties Company|Methods of reducing microbial contamination|

US7874467B2|2005-11-03|2011-01-25|Reseal International Limited Partnership|Metered drop push button dispenser system|

GB0505723D0|2005-03-19|2005-04-27|Smiths Group Plc|Tube placement apparatus and methods|

FR2884170B1|2005-04-08|2007-10-12|Rhodia Chimie Sa|USE OF A SILOXANE-BASED COMPOSITION FOR THE MOLDING-DEMOLDING OF TIRES|

WO2006116213A2|2005-04-22|2006-11-02|Karrie Ann Sancho|Antimicrobial spray for use on pets|

US7147634B2|2005-05-12|2006-12-12|Orion Industries, Ltd.|Electrosurgical electrode and method of manufacturing same|

US20060259012A1|2005-05-13|2006-11-16|Tri-State Hospital Supply Corporation|PIV high pressure infusion set|

US7651990B2|2005-06-13|2010-01-26|3M Innovative Properties Company|Foamable alcohol compositions comprising alcohol and a silicone surfactant, systems and methods of use|

JP2007016096A|2005-07-06|2007-01-25|Chugoku Marine Paints Ltd|Curable composition, composition for coating, coating material, antifouling coating material, cured product thereof and antifouling method of base material|

US7494339B2|2005-08-10|2009-02-24|Dentsply International, Inc.|Compositions for use as dental crowns and methods for preparing dental crowns|

US8343523B2|2005-08-22|2013-01-01|Quick-Med Technologies, Inc.|Disinfectant with durable activity based on alcohol-soluble quaternary ammonium polymers and copolymers|

US20070048344A1|2005-08-31|2007-03-01|Ali Yahiaoui|Antimicrobial composition|

US20070083162A1|2005-10-11|2007-04-12|Span-America Medical Systems, Inc.|Valve for intravenous catheter|

CA2625471C|2005-10-11|2014-06-17|Covidien Ag|Iv catheter with in-line valve and methods related thereto|

US8641684B2|2005-10-11|2014-02-04|Nxstage Medical, Inc.|Closure for tubular access port|

DE102005050186A1|2005-10-18|2007-04-19|Dreve Otoplastik Gmbh|Low viscosity, radiation-hardenable composition for antimicrobial medical products, especially adaptive ear pieces, is based on e.g. acrylates, glass or silver antimicrobials and photoinitiators |

US8227050B1|2005-10-31|2012-07-24|E I Du Pont De Nemours And Company|Coating composition and method for coating substrates|

JP5033637B2|2005-11-01|2012-09-26|テルモ株式会社|Indwelling needle assembly|

US7863361B2|2005-11-15|2011-01-04|Momentive Performance Materials Inc.|Swollen silicone composition, process of producing same and products thereof|

US8017687B2|2005-11-15|2011-09-13|Momentive Performance Materials Inc.|Swollen silicone composition and process of producing same|

US20070154621A1|2005-11-18|2007-07-05|Issam Raad|Methods for coating surfaces with antimicrobial agents|

US20070129690A1|2005-12-02|2007-06-07|Joel Rosenblatt|Catheter with polymeric coating|

WO2007070440A2|2005-12-09|2007-06-21|Pliant Corporation|Selectively permeable films|

EP1973587B1|2005-12-12|2019-02-06|AllAccem, Inc.|Methods and systems for preparing antimicrobial films and coatings|

US7896650B2|2005-12-20|2011-03-01|3M Innovative Properties Company|Dental compositions including radiation-to-heat converters, and the use thereof|

US7462401B2|2005-12-23|2008-12-09|Xerox Corporation|Radiation curable composition|

US20070160547A1|2006-01-11|2007-07-12|Janet Duffy|Method of applying a composition|

US20070166344A1|2006-01-18|2007-07-19|Xin Qu|Non-leaching surface-active film compositions for microbial adhesion prevention|

ES2877071T3|2006-02-14|2021-11-16|Allegiance Corp|Liquid applicator and procedure to reduce the concentration of antiseptic by-products|

MX2008010525A|2006-02-17|2009-01-27|Alan L Buchman|Catheter cleaning devices.|

CA2635932C|2006-02-23|2014-05-27|E.I. Du Pont De Nemours And Company|Removable antimicrobial coating compositions and methods of use|

US8623446B2|2006-02-25|2014-01-07|Metascape Llc|Ultraviolet activated antimicrobial surfaces|

ES2645681T3|2006-02-28|2017-12-07|Becton, Dickinson And Company|Antimicrobial compositions and methods to block catheters|

ES2780373T3|2006-03-01|2020-08-25|Becton Dickinson Co|Optimization method for fluid flow parameters of an extravascular system|

US20070281198A1|2006-06-01|2007-12-06|Lousenberg Robert D|Membranes electrode assemblies prepared from fluoropolymer dispersions|

US8167847B2|2006-06-22|2012-05-01|Excelsior Medical Corporation|Antiseptic cap and antiseptic cap equipped plunger and syringe barrel assembly|

US20080033371A1|2006-06-26|2008-02-07|Updegraff Debra K|Cover for catheter assembly|

US8815275B2|2006-06-28|2014-08-26|Boston Scientific Scimed, Inc.|Coatings for medical devices comprising a therapeutic agent and a metallic material|

US8197452B2|2006-07-28|2012-06-12|Becton, Dickinson And Company|Vascular access device non-adhering surfaces|

US20080027410A1|2006-07-28|2008-01-31|Becton, Dickinson And Company|Vascular access device non-adhering membranes|

US8512294B2|2006-07-28|2013-08-20|Becton, Dickinson And Company|Vascular access device antimicrobial materials and solutions|

JP2008043445A|2006-08-11|2008-02-28|Medikit Kk|Catheter, hollow needle and dwelling needle assembly|

US20100113871A1|2006-09-13|2010-05-06|Aylvin Jorge Angelo Athanasius Dias|Antimicrobial coating|

US10188826B2|2006-09-29|2019-01-29|Covidien Lp|Catheters including antimicrobial sleeve and methods of making catheters|

US8062266B2|2006-10-11|2011-11-22|Becton, Dickinson And Company|Vascular access device including a tear-resistant septum|

US8308691B2|2006-11-03|2012-11-13|B. Braun Melsungen Ag|Catheter assembly and components thereof|

US7832251B2|2006-11-15|2010-11-16|Abbott Laboratories|Patterned mold for medical device|

WO2008064111A2|2006-11-17|2008-05-29|Boston Scientific Limited|Radiopaque medical devices|

US7819842B2|2006-11-21|2010-10-26|Medtronic, Inc.|Chronically implantable guide tube for repeated intermittent delivery of materials or fluids to targeted tissue sites|

US20080140022A1|2006-12-08|2008-06-12|Warsaw Orthopedic, Inc.|Coated Cannula with Protective Tip for Insertion Into a Patient|

US8029753B2|2006-12-20|2011-10-04|Richard D Breault|Ammonia contact scrubber system for a fuel cell|

US8523830B2|2007-01-16|2013-09-03|Catheter Connections|Disinfecting caps for medical female luer connectors|

US8197749B2|2007-01-16|2012-06-12|The University Of Utah Research Foundation|Methods for cleaning luer connectors|

JP4909097B2|2007-01-17|2012-04-04|日本コヴィディエン株式会社|Indwelling needle|

EP2117494A4|2007-01-29|2012-03-28|Bisco Inc|Dental primer adhesive system and optional hydrophobic resin|

JP5571548B2|2007-04-18|2014-08-13|ビーエーエスエフソシエタス・ヨーロピア|Antimicrobial plastics and coatings|

US8591994B2|2007-04-25|2013-11-26|Ciba Corporation|Substrates with biocidal coating|

EP2156858A4|2007-06-12|2018-01-24|Terumo Kabushiki Kaisha|Method of producing indwelling needle assembly and indwelling needle assembly|

EP2011831B1|2007-07-03|2013-10-23|Shin-Etsu Chemical Co., Ltd.|Coating composition and a coating therefrom having waterdrop sliding property|

MX2010000589A|2007-07-16|2010-07-29|Bard Inc C R|Foley catheter having sterile barrier.|

GB0716605D0|2007-08-24|2007-10-03|Univ Aston|Skin antiseptics|

US20090101152A1|2007-10-17|2009-04-23|Marc Burk|High surface area anti-microbial coated endotracheal tube|

US8052829B2|2007-10-26|2011-11-08|Dymax Corporation|Photopolymerizable compositions containing an oxonol dye|

CN101868278B|2007-10-30|2013-04-10|美德乐控股公司|Device for connecting a suction hose|

CN101925837B|2007-11-30|2013-01-30|康宁股份有限公司|Dense homogeneous fluoride films for DUV elements and method of preparing same|

US10232140B2|2007-12-18|2019-03-19|Becton, Dickinson And Company|Anti-occlusion catheter adapter|

US8048471B2|2007-12-21|2011-11-01|Innovatech, Llc|Marked precoated medical device and method of manufacturing same|

US7811623B2|2007-12-21|2010-10-12|Innovatech, Llc|Marked precoated medical device and method of manufacturing same|

US8231927B2|2007-12-21|2012-07-31|Innovatech, Llc|Marked precoated medical device and method of manufacturing same|

US20090176907A1|2008-01-08|2009-07-09|Ramesh Subramanian|Direct-to-metal radiation curable compositions|

CA2713812A1|2008-01-30|2009-08-06|Building Solutions Ip Company, Llc|Ultraviolet cured coating system|

US8353876B2|2008-01-30|2013-01-15|Becton, Dickinson And Company|Occlusion resistant catheters|

US8202251B2|2008-03-14|2012-06-19|Access Scientific, Inc.|Access device|

US9572904B2|2008-05-06|2017-02-21|Michael J. Ferlic|Sterilizing device with pinch actuated cap and housing|

US9101748B2|2008-05-08|2015-08-11|Becton, Dickinson And Company|Push-button blood control|

US8291570B2|2008-05-30|2012-10-23|Boston Scientific Scimed, Inc.|Methods for abluminally coating medical devices|

US8034455B2|2008-06-06|2011-10-11|Novasolar Holdings Limited|Coating composition, substrates coated therewith and methods of making and using same|

US8178120B2|2008-06-20|2012-05-15|Baxter International Inc.|Methods for processing substrates having an antimicrobial coating|

US8277826B2|2008-06-25|2012-10-02|Baxter International Inc.|Methods for making antimicrobial resins|

US20090324738A1|2008-06-30|2009-12-31|Baxter International Inc.|Methods for making antimicrobial coatings|

WO2010009335A1|2008-07-17|2010-01-21|Micell Technologies, Inc.|Drug delivery medical device|

CN101353545B|2008-08-26|2010-06-23|苏州市明大高分子科技材料有限公司|UV curing antibiotic coating and preparation thereof|

US8511638B2|2008-09-05|2013-08-20|Carefusion 303, Inc.|Neonatal Luer-activated medical connector|

US20100069854A1|2008-09-12|2010-03-18|Onajite Okoh|Elastomeric Devices Containing Chlorhexidine/Fatty Acid Salts Made From Fatty Acids of 12 to 18 Carbons|

DE102008048988A1|2008-09-25|2010-04-08|Fresenius Kabi Deutschland Gmbh|Device for connecting a syringe to a container or a hose line|

US9022984B2|2008-10-27|2015-05-05|Pursuit Vascular, Inc.|Apparatus for delivery of device and antimicrobial agent into trans-dermal catheter|

US8622996B2|2008-10-27|2014-01-07|Pursuit Vascular, Inc.|Method for applying antimicrobial to proximal end of catheter|

US9078992B2|2008-10-27|2015-07-14|Pursuit Vascular, Inc.|Medical device for applying antimicrobial to proximal end of catheter|

US8622995B2|2009-10-26|2014-01-07|Pursuit Vascular, Inc.|Method for delivery of antimicrobial to proximal end of catheter|

US20100135949A1|2008-12-01|2010-06-03|Becton, Dickinson And Company|Antimicrobial compositions|

DE102008044296A1|2008-12-02|2010-07-01|Weizsäcker, Fritz von, Prof. Dr. Dr.h.c.|Indwelling catheter i.e. intravenous indwelling catheter, for e.g. blood transfusion, has sealing valve opened during exceedance of pressure difference of specific value in distal direction and permitting fluid flow in distal direction|

US7704935B1|2009-01-06|2010-04-27|Becton, Dickinson And Company|Chlorhexidine acetate antiseptic cleaning agent|

US8343525B2|2009-12-22|2013-01-01|Becton, Dickinson And Company|Chlorhexidine acetate antiseptic cleaning agent|

JP2010174075A|2009-01-27|2010-08-12|Panasonic Electric Works Co Ltd|Resin composition for forming anti-allergen coating film, wood plate and method for producing the same|

US8469928B2|2009-02-11|2013-06-25|Becton, Dickinson And Company|Systems and methods for providing a flushable catheter assembly|

US8679063B2|2009-02-11|2014-03-25|Becton, Dickinson And Company|Systems and methods for providing a catheter assembly|

US8574203B2|2009-02-11|2013-11-05|Becton, Dickinson And Company|Systems and methods for providing a flushable catheter assembly|

US8496623B2|2009-03-02|2013-07-30|Becton, Dickinson And Company|Bi-directional cannula feature capture mechanism|

US20100228178A1|2009-03-06|2010-09-09|Mcgraw J Kevin|Hemodialysis catheter apparatus|

US8357121B2|2009-03-26|2013-01-22|Becton, Dickinson And Company|Systems and methods for providing a safety integrated catheter with universal grip|

ES2505242T3|2009-04-01|2014-10-09|C.R. Bard, Inc.|Microbial rubbing device|

US20110146680A1|2009-06-25|2011-06-23|Conway Anthony J|Silicone catheter containing chlorhexidine gluconate|

US8821455B2|2009-07-09|2014-09-02|Becton, Dickinson And Company|Antimicrobial coating for dermally invasive devices|

DE102009026172A1|2009-07-14|2011-01-27|Hans Jürgen Hopf Betriebsgesellschaft|Reusable stopcock and method for its production|

DE202009009602U1|2009-07-15|2009-12-10|B. Braun Melsungen Ag|Catheter device with needle guard|

US8388583B2|2009-08-20|2013-03-05|Becton, Dickinson And Company|Systems and methods for providing a flushable catheter assembly|

US20110065798A1|2009-09-17|2011-03-17|Becton, Dickinson And Company|Anti-infective lubricant for medical devices and methods for preparing the same|

US8133423B2|2009-10-20|2012-03-13|The Hong Kong Polytechnic University|Method for fabrication of silicone composite with antimicrobial coating|

DE202009013408U1|2009-10-23|2011-03-03|Hopf, Hans-Jürgen|Multi-way tap with antiseptic or antimicrobial surfaces|

US20120078203A1|2010-01-13|2012-03-29|Gaube Gary J|Antimicrobial injection port barrier cover|

US8956327B2|2010-02-08|2015-02-17|Access Scientific, Llc|Access device|

US8825129B2|2010-03-05|2014-09-02|Sri International|Indwelling nerve block catheters|

CN102639162B|2010-03-26|2015-03-25|泰尔茂株式会社|Process for production of antimicrobial medical instrument, and antimicrobial medical instrument|

US20110301553A1|2010-06-04|2011-12-08|Smiths Medical Asd, Inc.|Antimicrobial lubricant|

US8652104B2|2010-06-25|2014-02-18|Smiths Medical Asd, Inc.|Catheter assembly with seal member|

US9480833B2|2010-07-15|2016-11-01|Becton, Dickinson And Company|Antimicrobial IV access cap|

US9028425B2|2010-07-15|2015-05-12|Becton, Dickinson And Company|Vented blood sampling device|

US8357119B2|2010-07-15|2013-01-22|Becton, Dickinson And Company|Catheter assembly and pierced septum valve|

US8932259B2|2010-09-13|2015-01-13|Becton, Dickinson And Company|Catheter assembly|

US9878143B2|2010-09-30|2018-01-30|Covidien Lp|Antimicrobial luer adapter|

EP2444117A1|2010-10-20|2012-04-25|Fresenius Kabi Deutschland GmbH|Protective cap for a connector|

JP5605636B2|2010-11-08|2014-10-15|ニプロ株式会社|Balloon catheter|

CN102070983A|2010-12-31|2011-05-25|上海参爱贸易有限公司|Antibacterial ultraviolet-curable coating|

US20120277576A1|2011-04-26|2012-11-01|Chun Kee Lui|Echogenic infusion port catheter|

WO2014159346A1|2013-03-14|2014-10-02|Excelsior Medical Corporation|Antiseptic dead-end cap|

US9867975B2|2011-05-23|2018-01-16|Excelsior Medical Corporation|Antiseptic line cap|

US10166381B2|2011-05-23|2019-01-01|Excelsior Medical Corporation|Antiseptic cap|

WO2013003373A1|2011-06-27|2013-01-03|3M Innovative Properties Company|Microstructured surfaces for reducing bacterial adhesion|

EP3714932A1|2011-07-12|2020-09-30|ICU Medical, Inc.|Device for delivery of antimicrobial agent into a transdermal catheter|

US9358364B2|2011-10-06|2016-06-07|Becton, Dickinson And Company|Activator attachment for blood control catheters|

US9155863B2|2011-10-06|2015-10-13|Becton, Dickinson And Company|Multiple use stretching and non-penetrating blood control valves|

US9126012B2|2011-10-06|2015-09-08|Becton, Dickinson And Company|Intravenous catheter with duckbill valve|

US9155876B2|2011-10-06|2015-10-13|Becton, Dickinson And Company|Port valve of a blood control catheter|

US20130196079A1|2012-01-27|2013-08-01|Reinhold Schwalm|Radiation-curable antimicrobial coating composition|

JP2015510791A|2012-03-06|2015-04-13|ピーエフエムメディカル，インコーポレイテッド|Antibacterial introducer and needle|

WO2013138534A1|2012-03-13|2013-09-19|Pfm Medical, Inc.|Catheter having antimicrobial coating|

US20130255061A1|2012-04-03|2013-10-03|Becton, Dickinson And Company|Systems and methods for applying a novel antimicrobial coating material to a medical device|

US9352119B2|2012-05-15|2016-05-31|Becton, Dickinson And Company|Blood control IV catheter with antimicrobial properties|

US9579486B2|2012-08-22|2017-02-28|Becton, Dickinson And Company|Blood control IV catheter with antimicrobial properties|

WO2014052283A1|2012-09-25|2014-04-03|Bausch & Lomb Incorporated|Polyether-polyamide plastics for surgical applications|

CN103055373A|2012-12-21|2013-04-24|钟冬秀|Anti-puncturing device of transfusion needle|

US8979802B2|2013-03-15|2015-03-17|B. Braun Melsungen Ag|Safety IV catheter assembly with seal|

EP2868722A1|2013-11-04|2015-05-06|Axinnove SAS|UV curable coating composition for antimicrobial coating|

JP6515084B2|2014-03-04|2019-05-15|テルモ株式会社|catheter|

EP3117863A4|2014-03-14|2017-10-25|Terumo Kabushiki Kaisha|Medical tube|

CA2943416C|2014-03-25|2019-10-29|Orthopaedic Innovation Centre Inc.|Antimicrobial articles produced by additive manufacturing|

US10376686B2|2014-04-23|2019-08-13|Becton, Dickinson And Company|Antimicrobial caps for medical connectors|

US9789279B2|2014-04-23|2017-10-17|Becton, Dickinson And Company|Antimicrobial obturator for use with vascular access devices|

US10232088B2|2014-07-08|2019-03-19|Becton, Dickinson And Company|Antimicrobial coating forming kink resistant feature on a vascular access device|

US10493244B2|2015-10-28|2019-12-03|Becton, Dickinson And Company|Extension tubing strain relief|US8366685B2|2011-04-26|2013-02-05|Creative Vascular, Llc|Systems and methods for phlebotomy through a peripheral IV catheter|

US9789279B2|2014-04-23|2017-10-17|Becton, Dickinson And Company|Antimicrobial obturator for use with vascular access devices|

US10376686B2|2014-04-23|2019-08-13|Becton, Dickinson And Company|Antimicrobial caps for medical connectors|

US9675793B2|2014-04-23|2017-06-13|Becton, Dickinson And Company|Catheter tubing with extraluminal antimicrobial coating|

US10232088B2|2014-07-08|2019-03-19|Becton, Dickinson And Company|Antimicrobial coating forming kink resistant feature on a vascular access device|

US20160073937A1|2014-09-11|2016-03-17|Becton, Dickinson And Company|Blood sampling system for improving draw success and reducing hemolysis|

US10493244B2|2015-10-28|2019-12-03|Becton, Dickinson And Company|Extension tubing strain relief|

LT3484535T|2016-07-14|2022-02-10|Hollister Incorporated|Hygienic medical devices having hydrophilic coating and methods of forming the same|

US10032552B2|2016-08-30|2018-07-24|Becton, Dickinson And Company|Cover for tissue penetrating device with integrated magnets and magnetic shielding|

KR20190130606A|2017-03-21|2019-11-22|벨라노 바스큘라, 인크.|Devices and Methods for Fluid Delivery Through a Deployed Peripheral Intravenous Catheter|

WO2018175529A1|2017-03-21|2018-09-27|Velano Vascular, Inc.|Systems and methods for controlling catheter device size|

US20190209809A1|2018-01-05|2019-07-11|Becton, Dickinson And Company|Echogenic catheter and catheter system|

US11207498B2|2019-08-20|2021-12-28|Velano Vascular, Inc.|Fluid transfer devices with extended length catheters and methods of using the same|

法律状态:
2019-08-27| B06U| Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette]|

2020-08-18| B09A| Decision: intention to grant [chapter 9.1 patent gazette]|

2020-11-17| B16A| Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]|Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 06/07/2015, OBSERVADAS AS CONDICOES LEGAIS. |

优先权:

申请号 | 申请日 | 专利标题

US14/326.036|2014-07-08|

US14/326,036|US10232088B2|2014-07-08|2014-07-08|Antimicrobial coating forming kink resistant feature on a vascular access device|

PCT/US2015/039261|WO2016007439A1|2014-07-08|2015-07-06|Antimicrobial coating forming kink resistant feature on a vascular access device|

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